The management of wound care is revolutionized by Negative Pressure Wound Therapy (NPWT). Sessions delve into its benefits, uses, and guiding principles. Its efficacy in treating surgical incisions, acute traumas, and chronic wounds is discussed. Furthermore, a number of NPWT modalities and dressing systems are reviewed, with a focus on how they might facilitate wound healing by lowering edema, improving blood flow, and encouraging the development of new tissue. The discourse delves into clinical results, optimal practices, and patient selection criteria, furnishing healthcare practitioners with crucial insights to enhance NPWT implementation and elevate patient care outcomes across a range of wound care contexts.