Title: Prevention and Improved Treatment of Diabetes using a Micronutrient Mixture, Probiotics, Omega3, and Collagen Peptides
Diabetes mellitus is a progressive chronic disease associated with enhanced levels of fasting glucose, HbA1C, and insulin resistance. Despite diabetic medications, which reduce the blood level of glucose but not the causes of the disease, complications such as retinopathy, nephropathy, peripheral neuropathy, and heart disease develop. External stressors which include poor diet and lifestyle, and excessive exposure to environmental toxins increase the levels of certain internal stressors such as oxidative stress and chronic inflammation. These internal stressors damage the insulin receptors causing accumulation of glucose in the blood leading to diabetes type II. Despite valuable recommendations for improving diet and lifestyle, and avoiding environmental toxins, the risk of developing diabetes type II continues to increase. In addition to elevated levels of oxidative stress and chronic inflammation, there are other internal stressors which include intestinal dysbiosis, omega-3-fatty acids dysfunction, oxidative damage to insulin receptors, and increased activity of dipeptidyl peptidase-4 (DPP-4), which prevents the secretion of insulin from the pancreas to the blood, contribute to the development and progression of diabetes type II. Addressing one of these internal stressors at a time may not produce an optimal benefit. To prevent and improve treatment of diabetes type II, this review proposes to address all external and internal stressors at the same. The proposal includes (a) adoption of good diet, healthy lifestyle, and reducing exposure to environmental toxins, (b) supplementation with a micronutrient mixture which would simultaneously reduce oxidative stress and chronic inflammation by elevating the levels of antioxidant enzymes and antioxidant compounds, (c) probiotics with prebiotics which would reverse the intestinal dysbiosis, (d) in patients with insulin resistance, omega-3-fatty acids directly activate the insulin receptor-linked signaling protein AKT which signals glucose transporter-4 (GLUT-4) to migrate to the cell surface and allows entry of glucose inside the cells, and (e) collagen peptides which increase the secretion of insulin by inhibiting dipeptidyl peptidase-4 (DPP-4) activity. The proposed plan may prevent and in combination with drugs may improve their effectiveness in diabetes type II.
Kedar N Prasad is associated with Engage Global Inc., located at USA.