Title: “Metabolic Dysregulation and Its Role in Postoperative Pain among Knee Osteoarthritis Patients”
The study aimed to investigate the association between POP development and disturbances in energy metabolic conversions, focusing on carbohydrate and fatty acid metabolism. Methods: Peripheral blood samples were collected from 26 healthy subjects and 50 patients with end-stage OA before joint replacement surgery. Pain levels were assessed before surgery using the visual analogue scale (VAS) and neuropathic pain questionnaires, DN4 and PainDETECT. Functional activity was evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Six months after surgery, pain indices according to a VAS of 30 mm or higher were considered.
Elena Tchetina is a Leading Scientist, Principle Investigator, Immunology & Molecular Biology Department, at Nasonova Research Institute of Rheumatology, Moscow, Russia
She conducts research in genetics, cellular, and molecular physiology of osteoarthritis, rheumatoid arthritis, and osteoporosis and investigates the importance of metabolic signalling pathways for the disease progression.